Evidence that the F2-isoprostane, 8-epi-prostaglandin F2α, is formed in vivo
作者： Jason D. Morrow , Tanya A. Minton , Kamal F. Badr , L.Jackson Roberts
DOI: 10.1016/0005-2760(94)90128-7
关键词: Isoprostane 、 Alpha (ethology) 、 Prostaglandin 、 Biosynthesis 、 Chemistry 、 In vivo 、 Biochemistry 、 Eicosanoid 、 Arachidonic acid 、 Lipid peroxidation
摘要: F2-isoprostanes are prostaglandin (PG)F2-like compounds that produced in vivo as non-enzymatic products of free radical catalyzed peroxidation arachidonic acid. One F2-isoprostane whose formation should be favored is 8-epi-PGF2 alpha. 8-Epi-PGF2 alpha has been shown to exert potent bioactivity but proof it formed lacking. Evidence now presented suggesting is, fact, by demonstrating an endogenous with a retention time on capillary GC identical co-chromatographs through four high resolving HPLC purification procedures authentic radiolabelled
elsevier.com
sci-hub.se 参考文章(8)
K Takahashi, T M Nammour, M Fukunaga, J Ebert, J D Morrow, L J Roberts, R L Hoover, K F Badr, Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. Journal of Clinical Investigation. ,vol. 90, pp. 136- 141 ,(1992) , 10.1172/JCI115826
Jason D. Morrow, Thomas M. Harris, L. Jackson Roberts, Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Analytical Biochemistry. ,vol. 184, pp. 1- 10 ,(1990) , 10.1016/0003-2697(90)90002-Q
J D Morrow, J A Awad, T Kato, K Takahashi, K F Badr, L J Roberts, R F Burk, Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. Journal of Clinical Investigation. ,vol. 90, pp. 2502- 2507 ,(1992) , 10.1172/JCI116143
J.D. Morrow, T.A. Minton, L.J. Roberts, The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist Prostaglandins. ,vol. 44, pp. 155- 163 ,(1992) , 10.1016/0090-6980(92)90077-7
K. H. Kang, J. D. Morrow, L. J. Roberts, J. H. Newman, M. Banerjee, Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung Journal of Applied Physiology. ,vol. 74, pp. 460- 465 ,(1993) , 10.1152/JAPPL.1993.74.1.460
Norman S. Radin, [44] Preparation of lipid extracts Methods in Enzymology. ,vol. 14, pp. 245- 254 ,(1969) , 10.1016/S0076-6879(69)14046-X
R. D. Smith, A. L. Goldin, Protein kinase A phosphorylation enhances sodium channel currents in Xenopus oocytes American Journal of Physiology-cell Physiology. ,vol. 263, ,(1992) , 10.1152/AJPCELL.1992.263.3.C660
M. Fukunaga, N. Makita, L. J. Roberts, J. D. Morrow, K. Takahashi, K. F. Badr, Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells American Journal of Physiology-cell Physiology. ,vol. 264, ,(1993) , 10.1152/AJPCELL.1993.264.6.C1619