Hereditary epidermolytic palmoplantar keratoderma associated with breast and ovarian cancer in a large kindred

摘要: SUMMARY We report a large kindred in which palmoplantar keratoderma occurred association with breast or ovarian cancer both. This consisted of 61 members four generations. Thirty-five individuals had keratoderma, including eight women who also Five the six and both have died. The proband presented yellowish, uniform hyperkeratosis surrounded by red border covering entire suface palms soles. Light microscopic examination showed features epidermolytic hyperkeratosis, ultrastructural revealed typical markers for this entity, cytolysis clumps keratin filaments. is first, to our knowledge, an internal malignancy.