Behandlung des nichtkleinzelligen Lungenkarzinoms

作者: N. Reinmuth , D. Heigener , M. Reck

DOI: 10.1007/S00108-011-2925-1

关键词: MedicineGynecology

摘要: Die Therapie des nichtkleinzelligen Lungenkarzinoms wurde in den letzten Jahren deutlich heterogener und umfangreicher. Neben neuen Chemotherapeutika wurden molekulare Therapieansatze entwickelt. Zudem mit der Erhaltungstherapie auch neue Therapieformen evaluiert. Durch die Analyse molekularer Marker konnen Patienten wahrscheinlichem Ansprechen auf bestimmte Medikamente identifiziert werden. Dieser Trend wird sich Zukunft fortsetzen durch eine zunehmende Bildung von molekular, histologisch oder klinisch definierten Patientensubgruppen charakterisiert sein. Der vorliegende Artikel gibt einen Uberblick uber aktuellen Wissensstand derzeitige Therapiestandards.

参考文章(26)
M. G. Kris, D. S. Ettinger, Ritsuko Komaki, R. J. Ginsberg, D. J. Sugarbaker, R. B. Livingston, J. D. Cox, NCCN Non-Small-Cell Lung Cancer Practice Guidelines. The National Comprehensive Cancer Network. Oncology. ,vol. 10, pp. 81- 111 ,(1996)
M. Kreuter, F.J.F. Herth, R. Eberhardt, Diagnostik des Bronchialkarzinoms Der Pneumologe. ,vol. 5, pp. 187- 198 ,(2008) , 10.1007/S10405-008-0231-Y
Ramón Rami-Porta, Vanessa Bolejack, John Crowley, David Ball, Jhingook Kim, Gustavo Lyons, Thomas Rice, Kenji Suzuki, Charles F Thomas Jr, William D Travis, Yi-Long Wu, Prognostic Factors Committee, None, The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer Journal of Thoracic Oncology. ,vol. 2, pp. 990- 1003 ,(2007) , 10.1097/JTO.0B013E31811F4703
Robert Pirker, Felix JF Herth, Keith M Kerr, Martin Filipits, Miquel Taron, David Gandara, Fred R Hirsch, Dominique Grunenwald, Helmut Popper, Egbert Smit, Manfred Dietel, Antonio Marchetti, Christian Manegold, Peter Schirmacher, Michael Thomas, Rafael Rosell, Federico Cappuzzo, Rolf Stahel, European EGFR Workshop Group, None, Consensus for EGFR Mutation Testing in Non-small Cell Lung Cancer: Results from a European Workshop Journal of Thoracic Oncology. ,vol. 5, pp. 1706- 1713 ,(2010) , 10.1097/JTO.0B013E3181F1C8DE
Filip Janku, Ignacio Garrido-Laguna, Lubos B. Petruzelka, David J. Stewart, Razelle Kurzrock, Novel therapeutic targets in non-small cell lung cancer. Journal of Thoracic Oncology. ,vol. 6, pp. 1601- 1612 ,(2011) , 10.1097/JTO.0B013E31822944B3
Charles A. Butts, Keyue Ding, Lesley Seymour, Philip Twumasi-Ankrah, Barbara Graham, David Gandara, David H. Johnson, Kenneth A. Kesler, Mark Green, Mark Vincent, Yvon Cormier, Glenwood Goss, Brian Findlay, Michael Johnston, Ming-Sound Tsao, Frances A. Shepherd, Randomized Phase III Trial of Vinorelbine Plus Cisplatin Compared With Observation in Completely Resected Stage IB and II Non–Small-Cell Lung Cancer: Updated Survival Analysis of JBR-10 Journal of Clinical Oncology. ,vol. 28, pp. 29- 34 ,(2010) , 10.1200/JCO.2009.24.0333
Ken A Olaussen, Ariane Dunant, Pierre Fouret, Elisabeth Brambilla, Fabrice André, Vincent Haddad, Estelle Taranchon, Martin Filipits, Robert Pirker, Helmut H Popper, Rolf Stahel, Laure Sabatier, Jean-Pierre Pignon, Thomas Tursz, Thierry Le Chevalier, Jean-Charles Soria, None, DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. The New England Journal of Medicine. ,vol. 355, pp. 983- 991 ,(2006) , 10.1056/NEJMOA060570
G. Goeckenjan, H. Sitter, M. Thomas, D. Branscheid, M. Flentje, F. Griesinger, N. Niederle, M. Stuschke, T. Blum, K.-M. Deppermann, J. Ficker, L. Freitag, A. Lübbe, T. Reinhold, E. Späth-Schwalbe, D. Ukena, M. Wickert, M. Wolf, S. Andreas, T. Auberger, R. Baum, B. Baysal, J. Beuth, H. Bickeböller, A. Böcking, R. Bohle, I. Brüske, O. Burghuber, N. Dickgreber, S. Diederich, H. Dienemann, W. Eberhardt, S. Eggeling, T. Fink, B. Fischer, M. Franke, G. Friedel, T. Gauler, S. Gütz, H. Hautmann, A. Hellmann, D. Hellwig, F. Herth, C. Heußel, W. Hilbe, F. Hoffmeyer, M. Horneber, R. Huber, J. Hübner, H.-U. Kauczor, K. Kirchbacher, D. Kirsten, T. Kraus, S. Lang, U. Martens, A. Mohn-Staudner, K.-M. Müller, J. Müller-Nordhorn, D. Nowak, U. Ochmann, B. Passlick, I. Petersen, R. Pirker, B. Pokrajac, M. Reck, S. Riha, C. Rübe, A. Schmittel, N. Schönfeld, W. Schütte, M. Serke, G. Stamatis, M. Steingräber, M. Steins, E. Stoelben, L. Swoboda, H. Teschler, H. Tessen, M. Weber, A. Werner, H.-E. Wichmann, E. Irlinger Wimmer, C. Witt, H. Worth, Prevention, diagnosis, therapy, and follow-up of lung cancer: interdisciplinary guideline of the German Respiratory Society and the German Cancer Society. Pneumologie. ,vol. 65, pp. 39- 59 ,(2011) , 10.1055/S-0030-1255961
Tony S. K. Mok, Suresh S. Ramalingam, Maintenance therapy in nonsmall-cell lung cancer: a new treatment paradigm. Cancer. ,vol. 115, pp. 5143- 5154 ,(2009) , 10.1002/CNCR.24563
William D Travis, Elisabeth Brambilla, Masayuki Noguchi, Andrew G Nicholson, Kim R Geisinger, Yasushi Yatabe, David G Beer, Charles A Powell, Gregory J Riely, Paul E Van Schil, Kavita Garg, John HM Austin, Hisao Asamura, Valerie W Rusch, Fred R Hirsch, Giorgio Scagliotti, Tetsuya Mitsudomi, Rudolf M Huber, Yuichi Ishikawa, James Jett, Montserrat Sanchez-Cespedes, Jean-Paul Sculier, Takashi Takahashi, Masahiro Tsuboi, Johan Vansteenkiste, Ignacio Wistuba, Pan-Chyr Yang, Denise Aberle, Christian Brambilla, Douglas Flieder, Wilbur Franklin, Adi Gazdar, Michael Gould, Philip Hasleton, Douglas Henderson, Bruce Johnson, David Johnson, Keith Kerr, Keiko Kuriyama, Jin Soo Lee, Vincent A Miller, Iver Petersen, Victor Roggli, Rafael Rosell, Nagahiro Saijo, Erik Thunnissen, Ming Tsao, David Yankelewitz, None, International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma Journal of Thoracic Oncology. ,vol. 6, pp. 244- 285 ,(2011) , 10.1097/JTO.0B013E318206A221