Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's disease

摘要: Alzheimer's disease (AD) and vascular dementia (VaD) are intertwined by mixed (MD) harboring varying degrees of AD pathology in combination with cerebrovascular disease. The aim was to assess whether there is a difference the cerebrospinal fluid (CSF) profile, selected proteins, between patients VaD MD subcortical (SVD), AD, healthy controls that could contribute separation groups. study included 30 controls, 26 SVD (9 17 MD) patients. protein panel total tau (T-tau), hyperphosphorylated 181 (P-tau(181)), amyloid β 1-42 (Aβ(1-42)), neurofilament light (NF-L), myelin basic (MBP), heart fatty acid binding (H-FABP), matrix metalloproteinases (MMP-1, -2, -3, -9, -10), tissue inhibitors (TIMP-1 -2). Immunochemical methods were utilized for quantification proteins CSF data analysis performed multivariate discriminant algorithm. concentrations MBP, TIMP-1, P-tau(181), NF-L, T-tau, MMP-9, Aβ(1-42), MMP-2 contributed most sensitivity 89% specificity 90% (AUC = 0.92). MBP NF-L best discriminating from while T-tau Aβ(1-42) segregating controls. biomarkers reflecting (T-tau, Aβ(1-42)), white matter lesions (NF-L MBP) remodeling (MMP-9 TIMP-1) perform well differentiating