Tolerance at high blood alcohol concentrations: a study of 110 cases and review of the literature.

作者: Joshua A. Perper , Abraham Twerski , Jerry W. Wienand

DOI: 10.1520/JFS11873J

关键词: Poison controlIncreased toleranceInjury controlDetoxificationPsychomotor learningBlood alcoholDrug toleranceMedicineInternal medicineSurgeryAlcohol

摘要: One hundred ten consecutive alcoholics who voluntarily entered a detoxification center were studied to determine their ability perform certain designated functions (a) while under the influence of alcohol at admission and (b) four days later, after they had undergone detoxification. Their blood concentrations (BACs) within an hour determined by using DuPont Automated Clinical Analyzer (ACA), following standard procedures. The results tests performed these subjects then ascertain level psychomotor impairment in elevated BACs. broken down age, sex, race, BAC. findings indicate that develop increased tolerance BACs, which are extremely high, including levels generally considered be potentially fatal.

参考文章(41)
L O'Daniel, Anesthetic management of the alcoholic patient. AANA journal. ,vol. 48, pp. 445- 451 ,(1980)
J M Littleton, Tolerance and physical dependence on alcohol at the level of synaptic membranes: a review. Journal of the Royal Society of Medicine. ,vol. 76, pp. 593- 601 ,(1983) , 10.1177/014107688307600713
Brismar B, Engström A, Rydberg U, Head injury and intoxication: a diagnostic and therapeutic dilemma. Acta chirurgica Scandinavica. ,vol. 149, pp. 11- 14 ,(1983)
P. Huguenard, Alain Astier, P. Hrouda, [Correlations between alcohol ingestion, blood alcohol levels and behavior problems]. Annales de l'anesthésiologie française. ,vol. 21, pp. 170- 182 ,(1980)
C. S. Lieber, Effect of Ethanol on the Activity of Microsomal Enzymes Springer Berlin Heidelberg. pp. 85- 92 ,(1971) , 10.1007/978-3-642-65131-1_11
Markku Kupari, C. J. Peter Eriksson, Juhani Heikkilä, Reino Ylikahri, Alcohol and the Heart Acta Medica Scandinavica. ,vol. 213, pp. 91- 98 ,(2009) , 10.1111/J.0954-6820.1983.TB03697.X
H. Kalant, B. M. Kapur, T. E. Reed, R. J. Gibbins, J. G. Rankin, Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds Canadian Medical Association Journal. ,vol. 115, pp. 851- 855 ,(1976)
S Holt, I C Stewart, J M Dixon, R A Elton, T V Taylor, K Little, Alcohol and the emergency service patient. BMJ. ,vol. 281, pp. 638- 640 ,(1980) , 10.1136/BMJ.281.6241.638
Susanne Keiding, Niels J. Christensen, Stig E. Damgaard, Anders Dejgåd, Henning L. Iversen, Anny Jacobsen, Søren Johansen, Frank Lundquist, Elisabeth Rubinstein, Kjeld Winkler, Ethanol metabolism in heavy drinkers after massive and moderate alcohol intake Biochemical Pharmacology. ,vol. 32, pp. 3097- 3102 ,(1983) , 10.1016/0006-2952(83)90255-1
N.W. Lawrence, M. Herbert, W.J. Jeffcoate, Circadian variation in effects of ethanol in man Pharmacology, Biochemistry and Behavior. ,vol. 18, pp. 555- 558 ,(1983) , 10.1016/0091-3057(83)90235-6