作者: Emma C. Barnes , Vanida Choomuenwai , Katherine T. Andrews , Ronald J. Quinn , Rohan A. Davis
DOI: 10.1039/C2OB00029F
关键词: Combinatorial chemistry 、 Eremophila Plant 、 Small Molecule Libraries 、 Amide 、 Chemistry 、 Hydrogen bond 、 Structure–activity relationship 、 Natural product 、 Ic50 values 、 Scaffold
摘要: The plant-derived natural product 14-hydroxy-6,12-muuroloadien-15-oic acid (1) was identified as a unique scaffold that could be chemically elaborated to generate novel lead- or drug-like screening libraries. Prior synthesis virtual library generated and prioritised based on physicochemical parameters such log P, D5.5, hydrogen bond donors/acceptors, molecular weight. isolated from the endemic Australian plant Eremophila mitchellii then utilised in parallel solution-phase generation of two series analogues. first consisted six semi-synthetic amide derivatives, whilst second contained carbamate These libraries have been evaluated for antimalarial activity using chloroquine-sensitive Plasmodium falciparum line (3D7) several compounds displayed low moderate with IC50 values ranging 14 33 μM.