Role of plasma membrane transporters in muscle metabolism.
作者： Antonio ZORZANO , César FANDOS , Manuel PALACÍN
DOI: 10.1042/BJ3490667
关键词: Membrane protein 、 Absorptive state 、 Glucose transporter 、 Glucose uptake 、 GLUT4 、 Efflux 、 Membrane transport 、 Metabolism 、 Biology 、 Biochemistry
摘要: Muscle plays a major role in metabolism. Thus it is glucose-utilizing tissue the absorptive state, and changes muscle insulin-stimulated glucose uptake alter whole-body disposal. In some conditions, preferentially uses lipid substrates, such as fatty acids or ketone bodies. Furthermore, main reservoir of amino protein. The activity many different plasma membrane transporters, carriers transporters carnitine, creatine acids, play crucial metabolism by catalysing influx efflux substrates across cell surface. cases, transport process subjected to intense regulatory control may become potential pharmacological target, case with transporter GLUT4. goal this review molecular characterization proteins, well analysis their possible role.
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