A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo.

作者: Gary W. Cline , Beat M. Jucker , Zlatko Trajanoski , Alexander J. M. Rennings , Gerald I. Shulman

DOI: 10.1152/AJPENDO.1998.274.2.E381

关键词: In vitroIn vivoCarbon-13 NMRNuclear magnetic resonance spectroscopyMeasurement methodInternal medicineIntracellularEndocrinologyHyperinsulinemiaSkeletal muscleChemistry

摘要: Intracellular glucose concentration in skeletal muscle of awake rats was determined under conditions hyperglycemic (10.2 ± 0.6 mM) hyperinsulinemia (∼1,200 pM) and (20.8 1.5 ...

参考文章(23)
David M. Kipnis, Ernst Helmreich, Carl F. Cori, Studies of tissue permeability. IV. The distribution of glucose between plasma and muscle. Journal of Biological Chemistry. ,vol. 234, pp. 165- 170 ,(1959) , 10.1016/S0021-9258(18)70357-8
G W Cline, I Magnusson, D L Rothman, K F Petersen, D Laurent, G I Shulman, Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. Journal of Clinical Investigation. ,vol. 99, pp. 2219- 2224 ,(1997) , 10.1172/JCI119395
Ronan Roussel, Pierre G. Carlier, Claire Wary, Gilberto Velho, Gilles Bloch, Evidence for 100% 13C NMR visibility of glucose in human skeletal muscle Magnetic Resonance in Medicine. ,vol. 37, pp. 821- 824 ,(1997) , 10.1002/MRM.1910370604
Z. Trajanoski, G. A. Brunner, L. Schaupp, M. Ellmerer, P. Wach, T. R. Pieber, P. Kotanko, F. Skrabal, Open-Flow Microperfusion of Subcutaneous Adipose Tissue for On-Line Continuous Ex Vivo Measurement of Glucose Concentration Diabetes Care. ,vol. 20, pp. 1114- 1121 ,(1997) , 10.2337/DIACARE.20.7.1114
D G Maggs, R Jacob, F Rife, R Lange, P Leone, M J During, W V Tamborlane, R S Sherwin, Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. Journal of Clinical Investigation. ,vol. 96, pp. 370- 377 ,(1995) , 10.1172/JCI118043
L Rossetti, D Smith, G I Shulman, D Papachristou, R A DeFronzo, Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. Journal of Clinical Investigation. ,vol. 79, pp. 1510- 1515 ,(1987) , 10.1172/JCI112981
S IYER, M KATOVICH, Fructose feeding in rats is not associated with sodium retention. American Journal of Hypertension. ,vol. 9, pp. 1018- 1023 ,(1996) , 10.1016/0895-7061(96)00113-6
E Ferrannini, J D Smith, C Cobelli, G Toffolo, A Pilo, R A DeFronzo, Effect of insulin on the distribution and disposition of glucose in man. Journal of Clinical Investigation. ,vol. 76, pp. 357- 364 ,(1985) , 10.1172/JCI111969