Performance Evaluation and Initial Clinical Test of the Positron Emission Mammography System (PEMi)

作者: Lin Li , Xiao-Yue Gu , Dao-Wu Li , Xian-Chao Huang , Pei Chai

DOI: 10.1109/TNS.2015.2457957

关键词: Image resolutionPhotomultiplierMedical imagingMedical physicsOpticsResolution (electron density)Materials sciencePositron emission mammographyFull width at half maximumSensitivity (control systems)Imaging phantom

摘要: A new polygon positron emission mammography imaging system (PEMi) was developed in 2009 by the Institute of High Energy Physics, Chinese Academy Sciences. PEMi is constructed a structure with lutetium yttrium orthosilicate crystal arrays mounted on position-sensitive photomultiplier. The consists 64 blocks and each block arranged $16 \times 16$ pixel size $1.9~\times 1.9~ 15$ mm. diameter detector ring 166 mm, axial length 128 mm. transaxial field view 110 mm. goal initial study to test PEMi’s performance clinical ability small group selected subjects. detectors have measured intrinsic spatial resolution averaging 1.67 mm. tangential remained under 2.5-mm full width at half maximum within central 5-cm view. hot rods 1.7 mm can be clearly identified, region containing 1.35-mm also observed. Using 6-ns coincidence timing window ${\hbox {360}} \sim {\hbox {660}}$ -keV energy window, peak sensitivity tomograph 6.88%. noise-equivalent count rate 110 $\thinspace$ 766 cps for breast-like cylindrical phantom 100 mm an activity concentration $0.03~\hbox{MBq}/{\rm cc}$ . recovery coefficients ranged from 0.21 0.85 between 1 mm 5 mm image-quality phantom. reconstructed image achieved improvement compared whole-body tomography (PET), which might reduce lower threshold detectable lesion size. Example patient images demonstrate that clinically feasible. And more detailed information obtained than PET imaging.

参考文章(29)
Raymond R Raylman, Jame Abraham, Hannah Hazard, Courtney Koren, Shannon Filburn, Judith S Schreiman, Sobha Kurian, Stan Majewski, Gary D Marano, Initial clinical test of a breast‐PET scanner Journal of Medical Imaging and Radiation Oncology. ,vol. 55, pp. 58- 64 ,(2011) , 10.1111/J.1754-9485.2010.02230.X
Benjamin M.W. Tsui, Martin G. Pomper, Yuchuan Wang, Juan J. Vaquero, Jurgen Seidel, Performance Evaluation of the GE Healthcare eXplore VISTA Dual-Ring Small-Animal PET Scanner The Journal of Nuclear Medicine. ,vol. 47, pp. 1891- 1900 ,(2006)
Jacobus J.M. van der Hoeven, Nanda C. Krak, Otto S. Hoekstra, Emile F.I. Comans, Robert P.A. Boom, Dick van Geldere, Sybren Meijer, Elsken van der Wall, Jan Buter, Herbert M. Pinedo, Gerrit J.J. Teule, Adriaan A. Lammertsma, 18F-2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography in Staging of Locally Advanced Breast Cancer Journal of Clinical Oncology. ,vol. 22, pp. 1253- 1259 ,(2004) , 10.1200/JCO.2004.07.058
N. Avril, C.A. Rosé, M. Schelling, J. Dose, W. Kuhn, S. Bense, W. Weber, S. Ziegler, H. Graeff, M. Schwaiger, Breast Imaging With Positron Emission Tomography and Fluorine-18 Fluorodeoxyglucose: Use and Limitations Journal of Clinical Oncology. ,vol. 18, pp. 3495- 3502 ,(2000) , 10.1200/JCO.2000.18.20.3495
S Grootoonk, T J Spinks, D Sashin, N M Spyrou, T Jones, Correction for scatter in 3D brain PET using a dual energy window method Physics in Medicine and Biology. ,vol. 41, pp. 2757- 2774 ,(1996) , 10.1088/0031-9155/41/12/013
C. J. Thompson, K. Murthy, I. N. Weinberg, F. Mako, Feasibility study for positron emission mammography Medical Physics. ,vol. 21, pp. 529- 538 ,(1994) , 10.1118/1.597169
S.R. Cherry, Y. Shao, R.W. Silverman, K. Meadors, S. Siegel, A. Chatziioannou, J.W. Young, W. Jones, J.C. Moyers, D. Newport, A. Boutefnouchet, T.H. Farquhar, M. Andreaco, M.J. Paulus, D.M. Binkley, R. Nutt, M.E. Phelps, MicroPET: a high resolution PET scanner for imaging small animals ieee nuclear science symposium. ,vol. 44, pp. 1161- 1166 ,(1996) , 10.1109/23.596981
Raymond R Raylman, Stan Majewski, Mark F Smith, James Proffitt, William Hammond, Amarnath Srinivasan, John McKisson, Vladimir Popov, Andrew Weisenberger, Clifford O Judy, Brian Kross, Srikanth Ramasubramanian, Larry E Banta, Paul E Kinahan, Kyle Champley, The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements. Physics in Medicine and Biology. ,vol. 53, pp. 637- 653 ,(2008) , 10.1088/0031-9155/53/3/009
Stefan Siegel, Danny F Newport, Bing Bai, Quanzheng Li, Richard M Leahy, Simon R Cherry, Yongfeng Yang, Yuan-Chuan Tai, Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging. Physics in Medicine and Biology. ,vol. 49, pp. 2527- 2545 ,(2004) , 10.1088/0031-9155/49/12/005
B. B. Koolen, W. V. Vogel, M. J. T. F. D. Vrancken Peeters, C. E. Loo, E. J. Th. Rutgers, R. A. Valdés Olmos, Molecular Imaging in Breast Cancer: From Whole-Body PET/CT to Dedicated Breast PET. Journal of Oncology. ,vol. 2012, pp. 438647- 438647 ,(2012) , 10.1155/2012/438647