A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome.

摘要: OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether clinically verified early MI may promote development insulin resistance, obesity and the metabolic syndrome (MetS). METHODS:: One hundred seventy-four offspring to patients with before 60 years age in population-based prospective Malmo Diet Cancer (MDC) study were recruited (positive history). As controls, we included 174 MDC participants without during 14 follow-up (negative MetS was defined according National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines, as BMI greater than 30 kg/m resistance top quartile homeostasis model assessment index 348 (mean 44 years, 49% women). RESULTS:: odds ratio, 95% confidence interval, for positive compared negative 2.05, 1.06-4.00 (P = 0.034) after adjustment age, sex, low-density lipoprotein cholesterol (LDL) smoking. also independently associated 2.50, 1.34-4.66 0.003), abdominal 2.01, 1.21-3.33 0.007) 1.97, 1.14-3.40 0.014), whereas there no association LDL All these relationships stronger men women. CONCLUSION:: Parental MetS, rather traditional cardiovascular disease factors such smoking, suggesting that primary preventive interventions targeted at weight reduction improvement sensitivity be particularly beneficial this subset population. (Less)