Dental and Maxillofacial Abnormalities in Long-Term Survivors of Childhood Cancer: Effects of Treatment with Chemotherapy and Radiation to the Head and Neck

摘要: Sixty-eight long-term survivors of childhood cancer were evaluated for dental and maxillofacial abnormalities. Forty-five patients had received radiation lymphoma, leukemia, rhabdomyosarcoma, miscellaneous tumors. Forty-three the 45 remaining 23 who not also chemotherapy. Dental abnormalities detected in 37 (82%) radiated patients. comprised foreshortening blunting roots, incomplete calcification, premature closure apices, delayed or arrested tooth development, caries. Maxillofacial trismus, abnormal occlusal relationships, facial deformities. The more severe those at an earlier age higher dosages. Possible chemotherapeutic effects five treatment tumors located outside head neck region acquired amelogenesis imperfecta, microdontia bicuspid teeth, a tendency toward thinning roots with enlarged pulp chamber. should be recognized as major consequence cancer, attempts to minimize eliminate such sequelae involve effective interaction between therapists, medical oncologists.