Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1
作者： Mengchen Lu , Hai-shan Zhou , Qi-Dong You , Zhengyu Jiang
DOI: 10.1021/ACS.JMEDCHEM.6B00775
关键词: Design synthesis 、 Fluorescence 、 Visualization 、 Nanotechnology 、 KEAP1 、 Specific detection 、 Chemistry 、 Function (biology) 、 Computational biology 、 Small molecule 、 Cellular homeostasis
摘要: Keap1 is a pluripotent protein which plays predominant role in cellular homeostasis and stress responses. Given that the environment quite dynamic versatile, further investigation of function depends on tools for specific real-time detection Keap1. Herein, we report development functional affinity-based small-molecule probes can overcome some shortcomings current methods be applied studying
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