Immune Function Effects of Dental Amalgam in Children

摘要: ABSTRACT Background Dental amalgam is a widely used restorative material containing 50 percent elemental mercury that emits vapor. No randomized clinical trials have determined whether there are adverse immunological effects associated with this low-level exposure in children. The objective of study was to evaluate subpopulation the participants New England Children's Amalgam Trial for vitro manifestations immunotoxic dental amalgam. Methods authors conducted trial which children requiring treatment were randomly assigned receive either posterior restorations or resin-based composite restorations. They assessed 66 children, aged 6 10 years, total white blood cell counts, specific lymphocyte (T-cell and B-cell) counts lymphocyte, neutrophil monocyte responsiveness across five-year period. Because small number participants, acknowledge exploratory nature has limited statistical power. Results mean tooth surfaces restored during period 7.8 group 10.1 group. In group, slight, but not statistically significant, decline T cells monocytes at five seven days after treatment; consistently observed no differences six, 12 60 months. Conclusions findings confirm leads increased, albeit low-level, mercury. analysis immune function, did cause overt deficits, although transient restoration placement. Clinical Implications These suggest minimal most likely do need be concern practitioners considering use material.