Gender and age effects on the continuous reaction times method in volunteers and patients with cirrhosis.

摘要: Minimal hepatic encephalopathy (MHE) is a metabolic brain disorder occurring in patients with liver cirrhosis. MHE lessens patient’s quality of life, but treatable when identified. The continuous reaction times (CRT) method used screening for MHE. Gender and age effects on the CRT are unknown may confound results. aim this study was to standardise outcomes gender effects. We studied 121 volunteers without known disease 181 cirrhosis by test. Reaction time an auditory signal measured 100 times, 10th, 50th, 90th percentiles were recorded, index calculated as 50th percentile/(90th percentile-10th percentile), measure intra-individual stability times. In volunteers, men reacted faster than women their slowed age. However, neither nor effect present regarding index. slower higher degree instability volunteers. Male female patients, tended slow As among there no or Age influenced both index, however, independent groups. Screening using therefore, identifies dysfunction rather