Psychomotor speed as a predictor of functional status in older chronic heart failure (CHF) patients attending cardiac rehabilitation

摘要: BACKGROUND The association among psychological, neuropsychological dysfunctions and functional/clinical variables in Chronic Heart Failure (CHF) has been extensively addressed literature. However, only a few studies investigated those associations the older population. PURPOSE To evaluate psychological/neuropsychological profile of CHF patients, to explore interrelation with clinical/functional identify potential independent predictors patients' functional status. METHODS This study was conducted multi-center observational design. following assessments were performed: anxiety (Hospital Anxiety Depression Scale, HADS), depression (Geriatric GDS), cognitive impairment (Addenbrooke's Cognitive Examination Revised, ACE-R), executive functions (Frontal Assessment Battery, FAB), constructive abilities (Clock Drawing Test, CDT), psychomotor speed alternated attention (Trail Making TMT-A/B), status (6-minute walking test, 6MWT) clinical (New York Association, NYHA; Brain Natriuretic Peptide, BNP; left ventricular ejection fraction, LVEF; end diastolic diameter, LVEDD; volume, LVEDV; tricuspid annular plane systolic excursion, TAPSE). RESULTS 100 patients (mean age: 74.9±7.1 years; mean LVEF: 36.1±13.4) included study. Anxious depressive symptoms observed 16% 24,5% respectively. Age related TMT-A CDT (r = 0.49, p<0.001 r -0.32, p 0.001, respectively), Log-BNP ACE-R-Fluency subtest, -0.22, 0.034), 6MWT ACE-R-Memory subtest 0.24, 0.031 0.005, respectively). Both ACE-R-Total score -0.25, 0.013 0.002, respectively) -0.23, 0.024). At multiple regression analysis, significant status: worse findings on associated shorter distance walked at 6MWT. CONCLUSIONS Psychological screening, along assessment (TMT-A), may provide useful information for undergoing cardiac rehabilitation.