The Oxidative Damage and Disbalance of Calcium Homeostasis in Brain of Chicken Induced by Selenium Deficiency
作者： Shi-Wen Xu , Hai-Dong Yao , Jian Zhang , Zi-Wei Zhang , Jin-Tao Wang
DOI: 10.1007/S12011-012-9552-0
关键词: Calcium 、 Calcium metabolism 、 Endocrinology 、 Biology 、 Internal medicine 、 Mitochondrion 、 Glutathione 、 Homeostasis 、 Oxidative stress 、 Selenium deficiency 、 Glutathione peroxidase
摘要: Dietary selenium (Se) deficiency can influence the function of brain. Our objective was to investigate effects Se on oxidative damage and calcium (Ca) homeostasis in brain chicken. In present study, 1-day-old chickens were fed either a commercial diet (as control group) with 0.15 mg/kg or Se-deficient L 0.033 for 75 days. Then, injury biomarkers examined, including histological analysis, ultrastructure assay, apoptosis assay. We also examined effect Se-containing antioxidative enzyme glutathione peroxidase (GSH-Px), level (GSH), Ca The results showed that levels GSH activity GSH-Px are seriously reduced by 33.8-96 % (P < 0.001), 24.51-27.84 20.70-64.24 0.01), respectively. we perform analysis assay find caused disorganized structure, mitochondria, fusion nuclear membrane nucleus shrinkage, higher rate increase 0.05 P 0.01 0.001) conclusion, demonstrated induced disbalance Similar mammals, is extremely susceptible deficiency.
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