Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis

作者: Leonor Sterin-Borda , Martha Gimeno , Enri Borda , Enrique del Castillo , Alvaro L. Gimeno

DOI: 10.1016/0090-6980(81)90041-1

关键词: EndocrinologyArachidonic acidCoronary arteriesChemistryCorticosteroneAgonistBiosynthesisProstaglandinProstacyclinThromboxaneInternal medicine

摘要: Abstract Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 prostacyclin (PGI 2 ) and arachidonic acid (AA) than those of normal dogs. The stimulatory effect the synthetic endoperoxide analogue U-46619, was significantly higher in condition preparations animals. On other hand, while PGI evoked a dose-dependent relaxation arteries, vessels were not relaxed by low concentration whereas ones produced distinct constrictor effect. Additionally, inhibitors prostaglandins thromboxane (TX) biosynthesis such as corticosterone, indomethacin, acetylsalicylic acid, imidazole L-8027, abolished AA coronaries constricted animals, this action being inhibited imidazol L-8027. present results suggests that: a) are more reactive an b) probably contract via participation TX like material. It is then plausible that could be tentatively ascribed production prostaglandin constricting substance including als probable generation TXA -like agonist.

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