Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.

摘要: Ischemic stroke is thought to have a polygenic basis, but identification of susceptibility genes and quantification associated risks been hampered by conflicting results from underpowered case-control studies. We performed meta-analysis all candidate gene association studies in ischemic stroke. Electronic databases were searched up until January 2003 for nested English-language journals relating the investigation any humans. Cases required neuroimaging evidence diagnosis. To maintain genetic homogeneity, only white adults included. Studies that evaluated quantitative traits or intermediate phenotypes excluded. Data 120 Pooled odds ratios (ORs) with 95% confidence intervals (CIs) random- fixed-effects models calculated. Of 32 studied, 15 polymorphisms identified which at least 3 had conducted. Statistically significant associations factor V Leiden Arg506Gln (OR, 1.33; CI, 1.12-1.58), methylenetetrahydrofolate reductase C677T 1.24; 1.08-1.42), prothrombin G20210A 1.44; 1.11-1.86), angiotensin-converting enzyme insertion/deletion 1.21; 1.08-1.35). These also most investigated genes, including 4588, 3387, 3028, 2990 cases, respectively. No statistically was detected next (factor XIII, apolipoprotein E, human platelet antigen type 1). There component common single major effect identified; rather, variants several each exerting modest effect, contribute risk findings important implications design future predictive testing other multifactorial diseases.