Weakened [corrected] taste-LPS association during endotoxin tolerance.

摘要: In naive individuals, the administration of bacterial lipopolysaccharide (LPS) provokes a rapid systemic increase in pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6, inducing an acute phase response including sickness behavior. Strong associative learning occurs when relevant gustatory/olfactory stimuli precede activation immune system, affecting long-term individual food selection nutritional strategies. Repeated LPS results development endotoxin tolerance status, characterized by drastic reduction LPS-induced cytokine response. Here we investigated how postprandial categorization taste (0.2% saccharin) changed after high dose (0.5 mg/kg i.p.) LPS-tolerant animals. Determination consummatory fluid intake revealed that, contrast to LPS-naive rats, taste-LPS association did not occur during tolerance. Ninety minutes single trial, plasma responses TNF-alpha, IL-1beta IL-6 were completely blunted animals, which also resulted low LPS-adipsogenic LPS-anorexic effects. These findings indicate that identical challenge can result different neuro-behavioral consequences depending on history individual, thus revealing part complex interconnection between neuro-endocrine systems regulating consumption infectious process.