Sequential optimization of a pelletization process in a fluid bed rotor granulator

摘要: The aim of this study was to determine the effect rotor speed, amount water sprayed and atomizing air pressure on size, size distribution shape pellets produced in a fluid bed granulator, using microcrystalline cellulose α-lactose monohydrate as starting materials. It is follow up based conclusions 3 full factorial design performed previously. Initially, new 2 with center points set up. However, results analysis variance, revealed lack fit linear model for factors. Therefore, original expanded central composite order second polynomial that then found describe data adequately. An increase added, resulted larger increased sphericity, while an speed decreased their sphericity. All above-mentioned effects were be statistically significant (p