Prognostic value of plasma d-dimer levels in patients with glioblastoma multiforme – Results from a pilot study

摘要: Glioblastoma multiforme (GBM), the most common primary tumor of central nervous system, is associated with a state hypercoagulability. We hypothesized that activity displayed by elevated d-dimer plasma levels and might be used as predictor survival in patients glioblastoma multiforme. studied effects on clinical outcomes obtained two to three weeks following histologic confirmation diagnosis GBM at surgery or needle biopsy, but prior chemotherapy radiation therapy, 23 patients. During median follow-up 7.3 months (interquartile range 3.5 22 months), we observed total 21 deaths (91.3%). Elevated were significantly mortality compared normal values (log rank p = 0.002). The adjusted hazard ratio for death was 10.8 (95% confidence interval, 1.3 93.1; 0.03), controls. Similar effect sizes revealed when analyzing association between progression-free Additionally, more likely suffer from venous thromboembolism 0.025). Our data support assumption are related adverse outcome GBM. However, our results need confirmed large, prospective cohort study.