Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition.
作者： Chiao-Yin Sun , Shih-Chung Chang , Mai-Szu Wu
DOI: 10.1371/JOURNAL.PONE.0034026
关键词: Epithelial–mesenchymal transition 、 Endocrinology 、 Kidney disease 、 Kidney 、 Renin–angiotensin system 、 Fibrosis 、 Uremia 、 Internal medicine 、 Indican 、 Chemistry 、 Losartan
摘要: Background Uremic toxins are considered to have a determinant pathological role in the progression of chronic kidney disease. The aim this study was define putative roles renal renin–angiotensin–aldosterone system (RAAS) and tubular epithelial-to-mesenchymal transition (EMT) fibrosis induced by (indoxyl sulfate) IS (p-cresol PCS.
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