Adaptive adjustment of the randomization ratio using historical control data

作者: Brian P Hobbs , Bradley P Carlin , Daniel J Sargent

DOI: 10.1177/1740774513483934

关键词: A priori and a posterioriTreatment comparisonHistorical controlStatisticsComputer scienceData miningRandomization RatioText mining

摘要: BackgroundProspective trial design often occurs in the presence of ‘acceptable’ historical control data. Typically, these data are only utilized for treatment comparison a posteriori retrospecti...

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