The Pharmacology and Potential Clinical Applications of Somatostatin and its Analogues

摘要: Somatostatin was discovered in 1971, by Guillerain and his colleagues during their search for the hypothalamic growth hormone-releasing factor. A peptide found ovine hypothalamus which inhibited release of hormone from cultured anterior pituitary cells.1,2 Determination its amino acid sequence3 indicated that it a tetradecapeptide with molecular weight 1639 (Figure 1). An identical later isolated porcine Schally coworkers.4 The named somatostatin belief releasing factor whose sole function to inhibit secretion hormone. It soon became evident, however, immunologic characteristics biologic activity present D cells pancreatic islets, D-like gastrointestinal tract, parafollicular thyroid gland, extrahypothalamic neurons both central peripheral nervous system various species, including man. Moreover, studies employing synthetic somatostatin5 demonstrated possessed wide spectrum activities addition inhibition