What have we learned from single ion channels

作者: David Colquhoun

DOI: 10.1113/JPHYSIOL.2007.131656

关键词: Cognitive scienceIon channel gatingPsychologySingle ionPerspective (graphical)

摘要: The only problem about being asked to write a perspective on the Colquhoun & Sakmann (1985) paper published in Journal of Physiology is that I'm not yet sure whether conclusions were quite right.

参考文章(16)
David Colquhoun, Chris Shelley, Chris Hatton, Nigel Unwin, Lucia Sivilotti, Nicotinic Acetylcholine Receptors Burger's Medicinal Chemistry and Drug Discovery. pp. 357- 405 ,(2003) , 10.1002/0471266949.BMC030
A. Mitra, G. D. Cymes, A. Auerbach, Dynamics of the acetylcholine receptor pore at the gating transition state Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15069- 15074 ,(2005) , 10.1073/PNAS.0505090102
ERWIN NEHER, BERT SAKMANN, Single-channel currents recorded from membrane of denervated frog muscle fibres Nature. ,vol. 260, pp. 799- 802 ,(1976) , 10.1038/260799A0
Interaction at end-plate receptors between different choline derivatives. Proceedings of The Royal Society B: Biological Sciences. ,vol. 146, pp. 369- 381 ,(1957) , 10.1098/RSPB.1957.0018
Steven M. Sine, Andrew G. Engel, Recent advances in Cys-loop receptor structure and function. Nature. ,vol. 440, pp. 448- 455 ,(2006) , 10.1038/NATURE04708
Relaxation and Fluctuations of Membrane Currents that Flow through Drug-Operated Channels Proceedings of The Royal Society B: Biological Sciences. ,vol. 199, pp. 231- 262 ,(1977) , 10.1098/RSPB.1977.0137
M.B. Jackson, B.S. Wong, C.E. Morris, H. Lecar, C.N. Christian, Successive openings of the same acetylcholine receptor channel are correlated in open time. Biophysical Journal. ,vol. 42, pp. 109- 114 ,(1983) , 10.1016/S0006-3495(83)84375-6
On the Stochastic Properties of Bursts of Single Ion Channel Openings and of Clusters of Bursts Philosophical Transactions of the Royal Society B. ,vol. 300, pp. 1- 59 ,(1982) , 10.1098/RSTB.1982.0156