Hyperhomocystéinémie et facteurs associés au cours des MICI : étude prospective chez 81 patients

摘要: BACKGROUND: A high prevalence (52%) of hyperhomocysteinemia is observed in Crohn disease (CD), however it not well documented ulcerative colitis (UC). Furthermore, the different works studying associated factors are different. AIM: Prospective evaluation inflammatory bowel (IBD) patients, risk and determination a potential colorectal carcinoma case hyperhomocysteinemia. PATIENTS AND METHODS: IBD patients followed our department were prospectively recruited between November 2003-September 2004. To be included should have passed coloscopy two years. Patients with kidney failure or drugs supposed, to interfere homocysteine metabolism (folates, vitamin B12, methotrexate) excluded from study. The following parameters analysed: age, sex, clinical activity indexes (CDAI for CAI colitis), length-extent type (CD UC), smoking, plasma homocystein concentration, folates B12. RESULTS: Eighty-one (60 CD, 21 UC, mean age 43.8 +/- 17.3) included, 30 had an active at inclusion 16 smokers. concentration was 55.6%. In univariate analysis low rate only factor (74 vs. 52.8%; P = 0.018). Smoking almost factor. multivariate analysis, folate hyperhomocysteinemia, OR 3.59 [1.27-10.17]. Five endoscopic lesions considered as precancerous described; these all CONCLUSION: UC CD. There possible link cancer Plasma must search substitutive treatment B12 necessary