FnIII Domains: Predicting Mechanical Stability
作者： Ross W.S. Rounsevell , Jane Clarke
DOI: 10.1016/J.STR.2003.12.006
关键词: Hierarchy (mathematics) 、 Crystallography 、 Mechanical stability 、 Chemistry 、 Protein folding 、 Fibronectins 、 Molecular dynamics 、 Binding site 、 Hydrogen bond 、 Chemical physics
摘要: Abstract The experimentally derived mechanical hierarchy of the different FnIII domains from fibronectin is well predicted here by Steered Molecular Dynamics simulations. In addition, critical hydrogen bond model proposed might explain behavior these under chemical conditions.
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sci-hub.se 参考文章(9)
Andres F. Oberhauser, Piotr E. Marszalek, Harold P. Erickson, Julio M. Fernandez, The molecular elasticity of the extracellular matrix protein tenascin Nature. ,vol. 393, pp. 181- 185 ,(1998) , 10.1038/30270
Emanuele Paci, Martin Karplus, Forced unfolding of fibronectin type 3 modules: an analysis by biased molecular dynamics simulations. Journal of Molecular Biology. ,vol. 288, pp. 441- 459 ,(1999) , 10.1006/JMBI.1999.2670
David Craig, Mu Gao, Klaus Schulten, Viola Vogel, None, Tuning the Mechanical Stability of Fibronectin Type III Modules through Sequence Variations Structure. ,vol. 12, pp. 21- 30 ,(2004) , 10.1016/J.STR.2003.11.024
M. Carrion-Vazquez, A. F. Oberhauser, S. B. Fowler, P. E. Marszalek, S. E. Broedel, J. Clarke, J. M. Fernandez, Mechanical and Chemical Unfolding of a Single Protein: A Comparison Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3694- 3699 ,(1999) , 10.1073/PNAS.96.7.3694
R. B. Best, S. B. Fowler, J. L. Toca-Herrera, J. Clarke, A simple method for probing the mechanical unfolding pathway of proteins in detail Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 12143- 12148 ,(2002) , 10.1073/PNAS.192351899
Matthias Rief, Mathias Gautel, Filipp Oesterhelt, Julio M Fernandez, Hermann E Gaub, Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM Science. ,vol. 276, pp. 1109- 1112 ,(1997) , 10.1126/SCIENCE.276.5315.1109
Andres F Oberhauser, Carmelu Badilla-Fernandez, Mariano Carrion-Vazquez, Julio M Fernandez, The mechanical hierarchies of fibronectin observed with single-molecule AFM Journal of Molecular Biology. ,vol. 319, pp. 433- 447 ,(2002) , 10.1016/S0022-2836(02)00306-6
Matthias Rief, Jaime Pascual, Matti Saraste, Hermann E Gaub, Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles. Journal of Molecular Biology. ,vol. 286, pp. 553- 561 ,(1999) , 10.1006/JMBI.1998.2466
Robert B. Best, Susan B. Fowler, José L. Toca Herrera, Annette Steward, Emanuele Paci, Jane Clarke, Mechanical Unfolding of a Titin Ig Domain: Structure of Transition State Revealed by Combining Atomic Force Microscopy, Protein Engineering and Molecular Dynamics Simulations Journal of Molecular Biology. ,vol. 330, pp. 867- 877 ,(2003) , 10.1016/S0022-2836(03)00618-1