Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations
作者： Michael J. Thirman , Heidi J. Gill , Robert C. Burnett , David Mbangkollo , Norah R. McCabe
DOI: 10.1056/NEJM199309233291302
关键词: Leukemia 、 Myeloid-Lymphoid Leukemia Protein 、 Chromosomal translocation 、 Cytogenetics 、 Acute leukemia 、 Lymphoma 、 Breakpoint 、 Cancer research 、 Biology 、 Acute lymphocytic leukemia
摘要: Background Translocations involving chromosome band 11q23 are very frequent in both acute lymphoblastic and myeloid leukemias the most common genetic alteration infants with leukemia. In all age groups phenotypes of leukemia, an translocation carries a poor prognosis. A major question has been whether one or several genes on implicated these leukemias. Previously, we identified chromosomal breakpoint region translocations subsequently cloned gene named MLL that spans breakpoint. Methods We isolated 0.74-kb BamHI fragment from complementary DNA (cDNA) clone gene. To determine incidence rearrangements patients abnormalities, analyzed 61 3 cell lines derived such patients, 20 non-Hodgkin's lymphoma aberrations. Results The cDNA probe detected 58 of...
sci-hub.se 参考文章(45)
J Nichols, SD Nimer, Transcription factors, translocations, and leukemia Blood. ,vol. 80, pp. 2953- 2963 ,(1992) , 10.1182/BLOOD.V80.12.2953.2953
W Kroes, A Brizard, C Charrin, R Slater, F Guilhot, J L Huret, E V Schoot, M F Bertheas, K Hählen, E van Leeuwen, Cytogenetic heterogeneity in t(11;19) acute leukemia : clinical, hematological and cytogenetic analyses of 48 patients : updated published cases and 16 new observations Leukemia. ,vol. 7, pp. 152- 160 ,(1993)
Drexler Hg, Thiel E, Ludwig Wd, Review of the incidence and clinical relevance of myeloid antigen-positive acute lymphoblastic leukemia. Leukemia. ,vol. 5, pp. 637- 645 ,(1991)
Pierre Fenaux, Sylvie Castaigne, Herve Dombret, Eric Archimbaud, Monica Duarte, Pierre Morel, Thierry Lamy, Herve Tilly, Agnes Guerci, Frederic Maloisel, None, All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases. Blood. ,vol. 80, pp. 2176- 2181 ,(1992) , 10.1182/BLOOD.V80.9.2176.2176
Z. Chen, N.J. Brand, A. Chen, S.J. Chen, J.H. Tong, Z.Y. Wang, S. Waxman, A. Zelent, Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. The EMBO Journal. ,vol. 12, pp. 1161- 1167 ,(1993) , 10.1002/J.1460-2075.1993.TB05757.X
Thomas W. Glover, Catalog of chromosome aberrations in cancer, 4th ed American Journal of Human Genetics. ,vol. 50, pp. 1354- 1355 ,(1992)
Michelle M. LeBeau, Rafael Espinosa, Janet D. Rowley, Harry Drabkin, Paul Erickson, Timothy W. McKeithan, Giuseppina Nucifora, Debra J. Birn, Diane Roulston, Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis Blood. ,vol. 81, pp. 2728- 2734 ,(1993) , 10.1182/BLOOD.V81.10.2728.2728
DC Arthur, CD Bloomfield, LL Lindquist, ME Jr Nesbit, Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance Blood. ,vol. 59, pp. 96- 99 ,(1982) , 10.1182/BLOOD.V59.1.96.BLOODJOURNAL59196
SD Smith, P McFall, R Morgan, M Link, F Hecht, M Cleary, J Sklar, Long-Term Growth of Malignant Thymocytes In Vitro Blood. ,vol. 73, pp. 2182- 2187 ,(1989) , 10.1182/BLOOD.V73.8.2182.2182