Total synthesis of (−)-elegansidiol by using an abnormal Beckmann fragmentation of Hajos ketone oxime as a key step
作者： Liya Cao , Jianwei Sun , Xinyan Wang , Rui Zhu , Haijian Shi
DOI: 10.1016/J.TET.2007.03.123
关键词: Stereochemistry 、 Elegansidiol 、 Total synthesis 、 Ketone 、 Fragmentation (cell biology) 、 Chemistry 、 Oxime 、 Organic chemistry 、 Biochemistry 、 Drug discovery
摘要: Abstract Abnormal Beckmann fragmentation of Hajos ketone oxime regioselectively forms a chiral 1-oxygenated 2,2-dimethyl-4-methylene-cyclohexan skeleton. Using this transformation as key step, the total synthesis (−)-elegansidiol, an oxygenated mono-carbocyclic sesquiterpenoid, was achieved.
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