Multiple myeloma, version 1.2020 featured updates to the NCCN guidelines

Elena Zamagni, Cristina Nanni, Katia Mancuso, Paola Tacchetti, Annalisa Pezzi, Lucia Pantani, Beatrice Zannetti, Ilaria Rambaldi, Annamaria Brioli, Serena Rocchi, Carolina Terragna, Marina Martello, Giulia Marzocchi, Enrica Borsi, Ilaria Rizzello, Stefano Fanti, Michele Cavo, PET/CT Improves the Definition of Complete Response and Allows to Detect Otherwise Unidentifiable Skeletal Progression in Multiple Myeloma Clinical Cancer Research. ,vol. 21, pp. 4384- 4390 ,(2015) , 10.1158/1078-0432.CCR-15-0396

Pieter Sonneveld, Ingo G.H. Schmidt-Wolf, Bronno van der Holt, Laila el Jarari, Uta Bertsch, Hans Salwender, Sonja Zweegman, Edo Vellenga, Annemiek Broyl, Igor W. Blau, Katja C. Weisel, Shulamiet Wittebol, Gerard M.J. Bos, Marian Stevens-Kroef, Christof Scheid, Michael Pfreundschuh, Dirk Hose, Anna Jauch, Helgi van der Velde, Reinier Raymakers, Martijn R. Schaafsma, Marie-Jose Kersten, Marinus van Marwijk-Kooy, Ulrich Duehrsen, Walter Lindemann, Pierre W. Wijermans, Henk M. Lokhorst, Hartmut M. Goldschmidt, Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial Journal of Clinical Oncology. ,vol. 30, pp. 2946- 2955 ,(2012) , 10.1200/JCO.2011.39.6820

Jens Hillengass, Kerstin Fechtner, Marc-André Weber, Tobias Bäuerle, Sofia Ayyaz, Christiane Heiss, Thomas Hielscher, Thomas M. Moehler, Gerlinde Egerer, Kai Neben, Anthony D. Ho, Hans-Ulrich Kauczor, Stefan Delorme, Hartmut Goldschmidt, Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma Journal of Clinical Oncology. ,vol. 28, pp. 1606- 1610 ,(2010) , 10.1200/JCO.2009.25.5356

International Myeloma Working Group, None, Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group British Journal of Haematology. ,vol. 121, pp. 749- 757 ,(2003) , 10.1046/J.1365-2141.2003.04355.X

E Zamagni, C Nanni, F Gay, A Pezzi, F Patriarca, M Bellò, I Rambaldi, P Tacchetti, J Hillengass, B Gamberi, L Pantani, V Magarotto, A Versari, M Offidani, B Zannetti, F Carobolante, M Balma, P Musto, M Rensi, K Mancuso, A Dimitrakopoulou-Strauss, S Chauviè, S Rocchi, N Fard, G Marzocchi, G Storto, P Ghedini, A Palumbo, S Fanti, M Cavo, 18F-FDG PET/CT focal, but not osteolytic, lesions predict the progression of smoldering myeloma to active disease. Leukemia. ,vol. 30, pp. 417- 422 ,(2016) , 10.1038/LEU.2015.291

Meletios A. Dimopoulos, Maria Roussou, Maria Gavriatopoulou, Erasmia Psimenou, Evangelos Eleutherakis-Papaiakovou, Magdalini Migkou, Charis Matsouka, Despoina Mparmparousi, Dimitra Gika, Eftychia Kafantari, Dimitrios Ziogas, Despoina Fotiou, Ioannis Panagiotidis, Evangelos Terpos, Efstathios Kastritis, Bortezomib‐based triplets are associated with a high probability of dialysis independence and rapid renal recovery in newly diagnosed myeloma patients with severe renal failure or those requiring dialysis American Journal of Hematology. ,vol. 91, pp. 499- 502 ,(2016) , 10.1002/AJH.24335

Meletios A Dimopoulos, Pieter Sonneveld, Nelson Leung, Giampaolo Merlini, Heinz Ludwig, Efstathios Kastritis, Hartmut Goldschmidt, Douglas Joshua, Robert Z Orlowski, Raymond Powles, David H Vesole, Laurent Garderet, Hermann Einsele, Antonio Palumbo, Michele Cavo, Paul G Richardson, Philippe Moreau, Jesús San Miguel, S Vincent Rajkumar, Brian GM Durie, Evangelos Terpos, None, International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment Journal of Clinical Oncology. ,vol. 34, pp. 1544- 1557 ,(2016) , 10.1200/JCO.2015.65.0044

C Pawlyn, L Fowkes, S Otero, J R Jones, K D Boyd, F E Davies, G J Morgan, D J Collins, B Sharma, A Riddell, M F Kaiser, C Messiou, Whole-body diffusion-weighted MRI: a new gold standard for assessing disease burden in patients with multiple myeloma? Leukemia. ,vol. 30, pp. 1446- 1448 ,(2016) , 10.1038/LEU.2015.338

Cyrille Hulin, Andrew Belch, Chaim Shustik, Maria Teresa Petrucci, Ulrich Dührsen, Jin Lu, Kevin Song, Philippe Rodon, Brigitte Pégourié, Laurent Garderet, Hannah Hunter, Isabelle Azais, Richard Eek, Heinz Gisslinger, Margaret Macro, Shaker Dakhil, Cristina Goncalves, Richard LeBlanc, Ken Romeril, Bruno Royer, Chantal Doyen, Xavier Leleu, Fritz Offner, Nicolas Leupin, Vanessa Houck, Guang Chen, Annette Ervin-Haynes, Meletios A. Dimopoulos, Thierry Facon, Updated Outcomes and Impact of Age With Lenalidomide and Low-Dose Dexamethasone or Melphalan, Prednisone, and Thalidomide in the Randomized, Phase III FIRST Trial Journal of Clinical Oncology. ,vol. 34, pp. 3609- 3617 ,(2016) , 10.1200/JCO.2016.66.7295

Joseph R. Mikhael, Craig B. Reeder, Edward N. Libby, Luciano J Costa, Peter Leif Bergsagel, Francis Buadi, Angela Mayo, Katherine Gano, Cassandra Wolf, Amylou Constance Dueck, A. Keith Stewart, A Phase I/II Trial Of Cyclophosphamide, Carfilzomib, Thalidomide and Dexamethasone (CYCLONE) In Patients With Newly Diagnosed Multiple Myeloma: Final Results Of MTD Expansion Cohort Blood. ,vol. 122, pp. 3179- 3179 ,(2013) , 10.1182/BLOOD.V122.21.3179.3179