Marcadores moleculares para la valoración clínica del nódulo tiroideo
作者： A. Rodríguez , T. Jiménez , P. Vidal-Ríos
DOI: 10.1016/S1575-0922(03)74498-2
关键词:
摘要: La puncion-aspiracion con aguja fina (PAAF) es generalmente aceptada como la tecnica de eleccion en el estudio del nodulo tiroideo; sin embargo, su interpretacion clinica tiene algunas limitaciones. Por ello, los ultimos anos se ha propuesto complementar citologia convencional marcadores moleculares detectados mediante tecnicas inmunoquimicas. Los mas estudiados son TPO47 y galectina-3, ambos notable sensibilidad especificidad. CD44v6 menos util lo que pensaba al principio. Sobre pRB, c-Met, CK-19, HBME-1, COX-2 hTERT, aunque muy prometedores, dispone experiencia. Existe una importante lista otros potenciales malignidad estan a espera ser analizados. Todos estos marcadores, empleados aisladamente o combinacion, podrian mejorar manera sustancial exactitud diagnostica PAAF casos dificiles asi evitar tiroidectomias innecesarias.
elsevier.es
unirioja.es参考文章(51)
M. Miettinen, P. K�rkk�inen, Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours. Preferential reactivity with malignant tumours. Virchows Archiv. ,vol. 429, pp. 213- 219 ,(1996) , 10.1007/BF00198336
M.J. Faroux, S. Theobald, M. Pluot, M. Patey, D. Menzies, Evaluation of the monoclonal antibody antithyroperoxidase MoAb47 in the diagnostic decision of cold thyroid nodules by fine-needle aspiration. Pathology Research and Practice. ,vol. 193, pp. 705- 712 ,(1997) , 10.1016/S0344-0338(97)80030-1
James Sebesta, Tommy Brown, William Williard, M.J Dehart, Wade Aldous, Jeffery Kavolius, Kenneth Azarow, Does telomerase activity add to the value of fine needle aspirations in evaluating thyroid nodules American Journal of Surgery. ,vol. 181, pp. 420- 422 ,(2001) , 10.1016/S0002-9610(01)00605-5
Nancy P. Caraway, Nour Sneige, Naguib A. Samaan, Diagnostic pitfalls in thyroid fine‐needle aspiration: A review of 394 cases Diagnostic Cytopathology. ,vol. 9, pp. 345- 350 ,(1993) , 10.1002/DC.2840090320
Tetsunari Oyama, Elji Ichimura, Takaaki Sano, Kenji Kashiwabara, Toshio Fukuda, Takashi Nakajima, c-Met expression of thyroid tissue with special reference to papillary carcinoma Pathology International. ,vol. 48, pp. 763- 768 ,(1998) , 10.1111/J.1440-1827.1998.TB03835.X
Catherine De Micco, Patricia Zoro, Stéphane Garcia, Lambert Skoog, Edneia M Tani, Pierre Carayon, Jean-Francois Henry, Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy. European Journal of Endocrinology. ,vol. 131, pp. 474- 479 ,(1994) , 10.1530/EJE.0.1310474
Junli Feng, Walter D Funk, Sy-Shi Wang, Scott L Weinrich, Ariel A Avilion, Choy-Pik Chiu, Robert R Adams, Edwin Chang, Richard C Allsopp, Jinghua Yu, Siyuan Le, Michael D West, Calvin B Harley, William H Andrews, Carol W Greider, Bryant Villeponteau, The RNA component of human telomerase Science. ,vol. 269, pp. 1236- 1241 ,(1995) , 10.1126/SCIENCE.7544491
Catherine De Micco, Vassili Vassko, Jean-François Henry, The value of thyroid peroxidase immunohistochemistry for preoperative fine-needle aspiration diagnosis of the follicular variant of papillary thyroid cancer Surgery. ,vol. 126, pp. 1200- 1204 ,(1999) , 10.1067/MSY.2099.101428
Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse, Joseph J. McDonald, Roderick A. Stegeman, Jina Y. Pak, Daniel Gildehaus, Julie M. iyashiro, Thomas D. Penning, Karen Seibert, Peter C. Isakson, William C. Stallings, Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. ,vol. 384, pp. 644- 648 ,(1996) , 10.1038/384644A0
Jane F. Desforges, Ernest L. Mazzaferri, Management of a Solitary Thyroid Nodule The New England Journal of Medicine. ,vol. 328, pp. 553- 559 ,(1993) , 10.1056/NEJM199302253280807