New antithrombotic agents in the ambulatory setting

作者: Neville M. Gibbs , William M. Weightman , Stephen A. Watts

DOI: 10.1097/ACO.0000000000000127

关键词: AntithromboticIntensive care medicineAnticoagulant AgentMEDLINEMultidisciplinary assessmentThrombotic riskRelative riskAmbulatoryMedicinePerioperativeAnesthesiology and Pain Medicine

摘要: Purpose of review Many patients presenting for surgical or other procedures in an ambulatory setting are taking new antiplatelet anticoagulant agents. This assesses how the novel features these agents affect management antithrombotic therapy setting. Recent findings There have been very few studies investigating relative risks continuing ceasing reviews indicate that offer greater efficacy ease administration but more difficult to monitor reverse. They emphasize importance assessing bleeding risk procedure, thrombotic if agent is ceased, and patient factors increase likelihood bleeding. The timing cessation agent, required, depends on its pharmacokinetics patients' risks. Patients at high complications may require bridging therapy. Once agreed upon, perioperative plan should be made clear all involved. Summary As there clinical guide management, clinicians must make rational decisions relation requires knowledge their pharmacokinetics, a careful multidisciplinary assessment individual patients.

参考文章(37)
Diana A. Gorog, Valentin Fuster, Platelet function tests in clinical cardiology: unfulfilled expectations. Journal of the American College of Cardiology. ,vol. 61, pp. 2115- 2129 ,(2013) , 10.1016/J.JACC.2012.11.080
D. GARCIA, Y. C. BARRETT, E. RAMACCIOTTI, J. I. WEITZ, Laboratory assessment of the anticoagulant effects of the next generation of oral anticoagulants. Journal of Thrombosis and Haemostasis. ,vol. 11, pp. 245- 252 ,(2013) , 10.1111/JTH.12096
Basel Assaad, Veronica Kemerko Sesi, Renzo Figari, Lonni Schultz, Nithin Thummala, Mohammed Rehman, Arun Chandok, Ann Silverman, Brian Silver, Antithrombotic Management of Stroke Patients Before Colonoscopy Journal of Stroke & Cerebrovascular Diseases. ,vol. 22, pp. 733- 736 ,(2013) , 10.1016/J.JSTROKECEREBROVASDIS.2011.12.006
Daniel E. Becker, Antithrombotic Drugs: Pharmacology and Implications for Dental Practice Anesthesia Progress. ,vol. 60, pp. 72- 80 ,(2013) , 10.2344/0003-3006-60.2.72
Todd H. Baron, Patrick S. Kamath, Robert D. McBane, Management of antithrombotic therapy in patients undergoing invasive procedures. The New England Journal of Medicine. ,vol. 368, pp. 2113- 2124 ,(2013) , 10.1056/NEJMRA1206531
Yuichi J Shimada, Robert P Giugliano, Emerging antithrombotic drugs for acute coronary syndrome Expert Opinion on Emerging Drugs. ,vol. 18, pp. 307- 318 ,(2013) , 10.1517/14728214.2013.819342
Jennifer L. Gordon, Timothy C. Fabian, Marilyn D. Lee, Marion Dugdale, Anticoagulant and antiplatelet medications encountered in emergency surgery patients: a review of reversal strategies. Journal of Trauma-injury Infection and Critical Care. ,vol. 75, pp. 475- 486 ,(2013) , 10.1097/TA.0B013E3182A07391
Ivan Philip, Clarisse Berroëta, Isabelle Leblanc, Perioperative challenges of atrial fibrillation Current Opinion in Anaesthesiology. ,vol. 27, pp. 344- 352 ,(2014) , 10.1097/ACO.0000000000000070
Vaani Panse Garg, Jonathan L. Halperin, Novel Antiplatelet and Anticoagulant Agents in the Cardiac Care Unit Cardiology Clinics. ,vol. 31, pp. 533- 544 ,(2013) , 10.1016/J.CCL.2013.07.001
Mike Makris, Joost J. Van Veen, Campbell R. Tait, Andrew D. Mumford, Mike Laffan, , Guideline on the management of bleeding in patients on antithrombotic agents. British Journal of Haematology. ,vol. 160, pp. 35- 46 ,(2013) , 10.1111/BJH.12107