Dual‐Function CXCR4 Antagonist Polyplexes To Deliver Gene Therapy and Inhibit Cancer Cell Invasion
作者： Jing Li , Yu Zhu , Stuart T. Hazeldine , Chunying Li , David Oupický
关键词: Cell culture 、 Cancer research 、 RNA interference 、 Cancer cell 、 Drug delivery 、 Transfection 、 Cancer 、 Chemistry 、 CXCR4 antagonist 、 Genetic enhancement 、 Molecular biology
摘要: A bicyclam-based biodegradable polycation with CXCR4 antagonistic activity was developed potential for combined drug/gene cancer therapies. The dual-function prevents cell invasion by inhibiting CXCL12 stimulated activation, while at the same time efficiently and safely delivers plasmid DNA into cells.
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