Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex
作者： Mingli Qi , Janice A. Williams , Hin Chu , Xuemin Chen , Jaang-Jiun Wang
DOI: 10.1371/JOURNAL.PPAT.1003278
关键词: Membrane protein 、 Cell membrane 、 Cell biology 、 Glycoprotein complex 、 Cytoplasm 、 Biology 、 Molecular biology 、 Endosome 、 Lipid microdomain 、 Wild type 、 Transport protein 、 Immunology 、 Genetics 、 Microbiology 、 Parasitology 、 Virology
摘要: The incorporation of the envelope glycoprotein complex (Env) onto developing particle is a crucial step in HIV-1 lifecycle. long cytoplasmic tail (CT) Env required for HIV particles T cells and macrophages. Here we identify Rab11a-FIP1C/RCP protein as an essential cofactor relevant human cells. Depletion FIP1C reduced tail-dependent manner, was rescued by replenishment FIP1C. redistributed out endosomal recycling to plasma membrane wild type but not CT-truncated Env. Rab14 incorporation, mutants incapable binding failed rescue incorporation. Expression led enhancement indicating that these trafficking factors are normally limiting CT-dependent particles. These findings support model which specific targeting assembly microdomain on mediated Rab14.
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