Immunophenotyping for diagnosis and prognosis in MDS: Ready for general application?
作者： Eline M.P. Cremers , Canan Alhan , Theresia M. Westers , Gert J. Ossenkoppele , Arjan A. van de Loosdrecht
DOI: 10.1016/J.BEHA.2014.11.003
关键词: Erythroid cell 、 Dysplasia 、 Myeloid leukemia 、 Bioinformatics 、 Myelodysplastic syndromes 、 Cytopenia 、 Immunophenotyping 、 Treatment response 、 Medicine 、 Heterogeneous group 、 Clinical biochemistry 、 Oncology
摘要: Myelodysplastic syndromes is a heterogeneous group of bone marrow diseases ranging from low risk to high subtypes that may rapidly evolve acute myeloid leukemia. Flow cytometry (FCM) added as recommended tool for diagnostic purposes in MDS. In recent studies FCM has also shown applicable predict prognosis and treatment response. This review summarizes current data about the diagnostic, prognostic therapeutic value The sensitivity detection dysplasia myelo-/monocytic erythroid cell lineages makes it valuable distinguish possible clonal causes cytopenia(s) non-clonal causes, detect multi-lineage addition cytomorphology. utility prediction response promising. Therefore, an essential standard strategies case suspected MDS, ready general application.
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