Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells
作者： HONG LI , JUAN MO , GUIZHI JIA , CHAO LIU , ZHIDONG LUAN
关键词: Cyclin-dependent kinase 8 、 Cell biology 、 Signal transduction 、 Cancer cell 、 Cell 、 Cancer 、 Oncogene 、 Carcinogenesis 、 Wnt signaling pathway 、 Biology
摘要: Notch and Wnt signaling play critical roles in the regulation of development diseases. Several studies have previously reported that may be a therapeutic target treatment various types human cancer. In this study, we report activation Notch1 inhibits proliferation BGC-823 gastric cancer cells. However, Wnt/β‑catenin pathway promotes growth Furthermore, combinational two pathways These data suggest overcomes pro-apoptotic role
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