Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression?

摘要: The evolution in the understanding of neurobiology most prevalent mental disorders such as major depressive disorder (MDD), bipolar or schizophrenia has not gone hand with synthesis and clinical use new drugs that would represent a therapeutic revolution brought about by selective serotonin reuptake inhibitors (SSRIs) atypical antipsychotics. Although scientists are still long way from its true aetiology, neurobiological concept depression evolved receptor regulation disorder, to neurodegenerative hippocampal volume decrease controversial reduction neurotrophins BDNF, current hypotheses consider be an inflammatory neuroprogressive process. As regards antidepressants, although researchers far knowing their mechanism action, they have monoaminergic hypotheses, which was main protagonist, emphasising anti-inflammatory action some these drugs, participation p11 protein action. In same way, according hypothesis depression, it been proposed NSAIDS aspirin like simvastatin could useful patients. Despite fact there may data support use, common sense evidence advise us already tested protocols wait for future undertake strategies.