Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography.

摘要: Purpose An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume on diffusion tensor imaging (DTI) tractography. It based using a shorter repetition (TR) by means slice re-ordering to reduce signal long T1 CSF and non-zero minimum weighting (b-value) attenuate rapidly diffusing with respect brain tissue. Methods A target reduction CSF/brain ratio from 3.5 0.8 required TR 2.5 s b-value 425 s/mm2. This was evaluated at 4.7 Tesla in eight healthy young adults tractography fornix, which has considerable contamination difficult track standard DTI. Results This effectively reduced relative yielded more robust tractography, increased tract volume, fractional anisotropy, decreased mean diffusivity fornix DTI. Conclusion CSF DTI can be mitigated through weighting. The lack RF increases attractive over other suppression methods such as inversion recovery. Magn Reson Med 73:1075–1084, 2015. © 2014 Wiley Periodicals, Inc.