Sleep Deprivation and Pain

摘要: Problematic sleep is one of the most common comorbidities for chronic pain patients. The association between and has long been recognized but nature relationship not well understood. current consensus that likely bidirectional, both reciprocally influencing another. In this review, we discuss available evidence from epidemiological, clinical, human as animal laboratory data on how poor impacts experimentally induced clinical pain, effects opioids sleep, therapeutic improvement reduction. Generally, literature supports positive pain. Sleep deprivation also seems to attenuate analgesic medications behavioral management techniques. disturbance may worsen with use opioids. a highly relevant parameter in problems, although research delineating causal or associative still preliminary at time. Continuing efforts experimental are needed develop translationally meaningful understanding