In vitro and in vivo evaluation of controlled-release matrix tablets of highly water-soluble drug applying different mw polyethylene oxides (PEO) as retardants
作者： Haoyang Wen , Xue Li , Yuenan Li , Haiying Wang , Yanyan Wang
DOI: 10.1080/03639045.2017.1405429
关键词: Organic chemistry 、 Drug 、 Matrix (chemical analysis) 、 Diltiazem hydrochloride 、 Chemistry 、 Polyethylene 、 Pharmacokinetics 、 Cmax 、 In vivo 、 Chromatography 、 Controlled release
摘要: The aim of the work presented is to prepare a controlled-release hydrophilic matrix tablet (CMT) controlling release highly water-soluble drug applying pure combination high- and low-Mw PEO as materials, avoid lag time release, overcome incomplete in later stages. influences types amounts different Mw PEOs used, loading, pH medium agitation rate on were evaluated. study uptake erosion was conducted mechanism improving discussed. In vivo pharmacokinetics CMT reference preparation self-made osmotic pump tablets (COPT) performed beagle dogs. optimized formulation containing 43% WSR 303 32% N750 showed zero order from 1 h 12 h. results demonstrated that had similar AUC0-48 h Cmax with COPT but smaller Tmax than provided more stable therapeutic concentration compare...
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