Constitutively active melatonin MT1 receptors in male rat caudal arteries
作者： Çaǧatay Erşahin , Monica I. Masana , Margarita L. Dubocovich
DOI: 10.1016/S0014-2999(02)01407-3
关键词: Melatonin 、 Inverse agonist 、 Artery 、 Endocrinology 、 Internal medicine 、 Basal (phylogenetics) 、 Circulatory system 、 Receptor 、 Biology 、 In vitro 、 Blood vessel 、 Pharmacology
摘要: Abstract This study assessed the state of melatonin MT 1 receptor coupling in sections male rat caudal arteries by [ 35 S]GTPγS binding autoradiography. The inverse agonist 4-phenyl-2-propionamidotetraline (4P-PDOT) (0.1–1 μM) significantly decreased compared to basal, strongly suggesting presence constitutively active receptors. Formation receptors during subjective day, when levels are low, may be a physiological mechanism which organism maintains vascular tone.
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