From parts lists to functional significance-RNA-protein interactions in gene regulation.

摘要: Hundreds of canonical RNA binding proteins facilitate diverse and essential processing steps in cells forming a central regulatory point gene expression. However, recent discoveries including the identification large number noncanonical bound to have changed our view on RNA-protein interactions merely as necessary biogenesis. As list interacting with has expanded, so scope regulation through interactions. In addition facilitating metabolism, help form subcellular structures membraneless organelles, provide means recruit components macromolecular complexes their sites action. Moreover, are not static but ribonucleoprotein (RNP) highly dynamic response cellular cues. The novel complex ways use these control functions continues broaden current challenge is move from cataloguing RNPs into assigning them functions. This will only understanding homeostasis may bring key insights human disease conditions where RNP play role. review brings together classical accomplished gained interactomes. We discuss challenges combining molecular mechanism journey towards comprehensive cells. article categorized under: Interactions Proteins Other Molecules > Protein-RNA Interactions: Functional Implications aRNA RNA-Protein Complexes Recognition.