Treatment of acute leukemia in adults

摘要: Improvement in the management of acute leukemia adults has not progressed nearly so rapidly as treatment childhood leukemia. One important difference is that most have myeloblastic or related forms disease (AML), whereas majority children lymphoblastic (ALL). However, even with ALL fail to respond well a similar regimen do same type In recent series patients who were treated complex multiple drug "L-2" protocol, incidence complete remission was 78% vs. 99% children, and median duration only 24 months adults, it yet been reached projected be over 4 years. AML nonlymphoblastic leukemia, therapy still unsatisfactory both children. With best current schedules, now better than 50%, but often difficult compare exact rates different because differences reporting results. "L-6" previously untreated 56% 10 months. The survival all (responders non-responders) 1 year responders 2 It encouraging significant proportion those remissions remain for extended periods; about 45% responding protocol remained year, 18% continuous Even after discontinuing treatment, some stay long periods, possible them may cured. If this proves true, becomes great importance determine what exceptionally compared continue die within year. no consistent nor distinctive favorable prognostic features identified.