Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.
作者： B. Daignan-Fornier , G. R. Fink
关键词: Purine riboswitch 、 Histidine 、 Promoter 、 Transcription (biology) 、 Purine 、 Biosynthesis 、 Biochemistry 、 Purine metabolism 、 Transcription factor 、 Biology
摘要: Abstract We have found cross-pathway regulation between purine and histidine biosynthesis in yeast. The transcription factors BAS1 BAS2/PHO2, which are also regulators of the pathway, participate biosynthetic pathway. Analysis four genes pathway (ADE1, ADE2, ADE5,7, ADE8) shows that their expression is repressed by adenine. maximal basal induced these requires presence both BAS2. factor has been shown to bind at a site containing TGACTC hexanucleotide motif ADE2 ADE5,7 promoters. This required for activation gene
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