Duration- and environment-dependent effects of repeated voluntary exercise on anxiety and cued fear in mice.
作者： Sarah Dubreucq , Giovanni Marsicano , Francis Chaouloff
DOI: 10.1016/J.BBR.2014.12.042
关键词: Social relation 、 Psychology 、 Anxiety 、 Developmental psychology 、 Audiology 、 Turnover 、 Test (assessment) 、 Elevated plus maze 、 Recall 、 Cued speech 、 Anxiolytic
摘要: Several studies have indicated that animal models of exercise, such as voluntary wheel running, might be endowed with anxiolytic properties. Using the light/dark test unconditioned anxiety, we reported one confounding factor in estimation running impacts on anxiety housing condition sedentary controls. The present mouse study analyzed whether aforementioned observation (i) could repeated elevated plus-maze and social interaction tests (ii) extended to conditioned assessed during cued fear recall tests, (iii) required unlimited daily access wheel. Housing a locked or free allowed limited activity triggered anxiolysis test, but not compared standard housing. In duration, number, contacts was increased mice provided (but limited) wheel, Lastly, freezing responses cue reduction observed wheels fully accounted for by Besides confirming controls bias effects this further shows is dependent used assess anxiety.
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