Personality factors correlate with regional cerebral perfusion

摘要: There is an increasing body of evidence pointing to a neurobiological basis personality. The purpose this study was investigate the biological bases major dimensions Eysenck's and Cloninger's models personality using noninvasive magnetic resonance perfusion imaging technique in 30 young, healthy subjects. An unbiased voxel-based analysis used identify regions where regional demonstrated significant correlation with any dimensions. Highly positive correlations emerged between extraversion basal ganglia, thalamus, inferior frontal gyrus cerebellum novelty seeking cerebellum, cuneus thalamus. Strong negative psychoticism ganglia thalamus harm avoidance cerebellar vermis, gyrus. These observations suggest that traits are strongly associated resting cerebral variety cortical subcortical provide further for hypothesized results may also have important implications functional neuroimaging studies, which typically rely on modulation hemodynamics detection task-induced activation since effects influence intersubject variability both task-related activity perfusion. This offers novel approach exploration correlates human