Liver transplantation

摘要: Liver transplantation has revolutionized the care of patients with end-stage liver disease. is indicated for acute or chronic failure from any cause. Because there are no randomized controlled trials versus therapy, efficacy this surgery best assessed by carefully comparing postoperative survival known natural history disease in question. The examples primary biliary cirrhosis and sclerosing cholangitis, which well-validated disease-specific models available. There currently relatively few absolute contraindications to transplantation. These include severe cardiopulmonary disease, uncontrolled systemic infection, extrahepatic malignancy, psychiatric neurological disorders, absence a viable splanchnic venous inflow system. One most frequently encountered ongoing destructive behavior caused drug alcohol addiction. timing can have profound impact on mortality morbidity undergoing long waiting lists donor organs, need project far advance when might be required proven one greatest challenges those treating Three important questions must addressed patient being considered transplantation: (1) should referred possible transplantation? (2) listed (3) too sick reasonable chance surviving perioperative period?