α‐Amino‐α‐vinyl‐γ‐butyrolactone Derivatives from α‐{[(Trimethylsilyl)methyl]alkylidene}‐γ‐butyrolactones
作者： Marinella Capuzzi , Augusto Gambacorta , Tecla Gasperi , M. Antonietta Loreto , P. Antonio Tardella
关键词: Chemistry 、 Tris 、 Stereochemistry 、 Aziridine 、 Ring (chemistry) 、 Trimethylsilyl 、 Stereoselectivity 、 Palladium
摘要: N-Protected α-amino-α-vinyl-γ-butyrolactones 1 are obtained by the aza-Michael-type addition of NsONHCO2Et to novel silylated α-ylidene-γ-butyrolactones 2, through ring opening intermediate aziridine and loss trimethylsilyl group. The stereoselective synthesis compounds cross-coupling reactions between α-[(triflyloxy)ylidene]-γ-butyrolactones 3 tris[(trimethylsilyl)methyl]aluminum, is also described. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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