Effects of an Estrogen Antagonist on Enzyme Activities and [3H]Estradiol Nuclear Binding in Uterus, Pituitary and Brain

摘要: The estrogenic and anti-estrogenic properties of CI-628 in the uterus, pituitary brain were assessed compared with those estradiol benzoate (EB) after vivo administration to ovariectomized (OVX) rats by measuring changes protein content, enzyme activities [3H]- nuclear binding. 1) EB led increased total glucose-6-phosphate dehydrogenase (G6PDH) activity uterus pituitary, choline acetylase (CAT) preoptic area decreased monoamine oxidase (MAO) corticomedial amygdala (CMamygdala). 2) mimicked all above except pituitary. dependent content less than half changes. In CM-amygdala, resulted approximately same CAT MAO as EB. 3) antagonized EB-dependent increase G6PDH activity. the...