Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches.

作者: Yoshiaki Maeda , Olga V. Makhlynets , Hiroshi Matsui , Ivan V. Korendovych

DOI: 10.1146/ANNUREV-BIOENG-111215-024421

关键词: Computational biologyNanotechnologyChemistryRational designContext (language use)Catalytic functionCombinatorial designProtein design

摘要: This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches creating activity classification of rational combinatorial classes. The section design covers the development short peptides oligomeric assemblies for natural unnatural reactions. describes advances discovery peptides. present future prospects these other new a broader context, including implications functional material design.

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